Tc-99m-exorphin-glucuronide in tumor diagnosis: Preparation and biodistribution studies in rats

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Atıf İçin Kopyala

Ertay T., ÜNAK P., Ozdogan O., Biber F. Z., ZİHNİOĞLU F., Medine E. I., ...Daha Fazla

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, cilt.269, sa.1, ss.21-28, 2006 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 269 Sayı: 1
• Basım Tarihi: 2006
• Doi Numarası: 10.1007/s10967-006-0226-2
• Dergi Adı: JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.21-28
• Dokuz Eylül Üniversitesi Adresli: Evet

Özet

A glucuronide derivative of exorphin C called exorphin C glucuronide was obtained by enzymatic synthesis and labeled with Tc-99m using glucoheptonate (GH) as bifunctional chelating agent. Labeling efficiency was 99.7 +/- 0.03%. Biodistribution studies were performed on normal and mammary tumor bearing albino Wistar rats. In addition, scintigraphic imaging with Tc-99m-GH-exorphin C glucuronide (Tc-99m-GEG) was performed. The radiopeptide-glucuronide is rapidly cleared via the urinary system showing lower liver uptake. Results demonstrated that Tc-99m-GEG can be used as a vehicle to target tumors.