Tc-99m-exorphin-glucuronide in tumor diagnosis: Preparation and biodistribution studies in rats

Ertay T., ÜNAK P., Ozdogan O., Biber F. Z., ZİHNİOĞLU F., Medine E. I., ...More

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, vol.269, no.1, pp.21-28, 2006 (SCI-Expanded) identifier identifier


A glucuronide derivative of exorphin C called exorphin C glucuronide was obtained by enzymatic synthesis and labeled with Tc-99m using glucoheptonate (GH) as bifunctional chelating agent. Labeling efficiency was 99.7 +/- 0.03%. Biodistribution studies were performed on normal and mammary tumor bearing albino Wistar rats. In addition, scintigraphic imaging with Tc-99m-GH-exorphin C glucuronide (Tc-99m-GEG) was performed. The radiopeptide-glucuronide is rapidly cleared via the urinary system showing lower liver uptake. Results demonstrated that Tc-99m-GEG can be used as a vehicle to target tumors.