Predictability of temporal network dynamics in normal ageing and brain pathology


Caligiuri A., Papo D., YENER G., GÜNTEKİN B., Galla T., Lacasa L., ...Daha Fazla

Journal of Complex Networks, cilt.14, sa.1, 2026 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 1
  • Basım Tarihi: 2026
  • Doi Numarası: 10.1093/comnet/cnaf058
  • Dergi Adı: Journal of Complex Networks
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Compendex, MathSciNet, zbMATH
  • Anahtar Kelimeler: functional networks, predictability, Parkinson's disease, Alzheimer's disease
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Spontaneous brain activity generically displays transient spatiotemporal coherent structures, which can selectively be affected in various neurological and psychiatric pathologies. Here we model the full brain’s electroencephalographic activity as a high-dimensional functional network performing a trajectory in a latent graph phase space. This approach allows us to investigate the orbital stability of brain’s activity and in particular its short-term predictability. We do this by constructing a non-parametric statistic quantifying the expansion of initially close functional network trajectories. We apply the method to cohorts of healthy ageing individuals, and patients previously diagnosed with Parkinson’s or Alzheimer’s disease. Results not only characterize brain dynamics from a new angle, but further show that functional network predictability varies in a marked scale-dependent way across healthy controls and patient groups. The path towards both pathologies is markedly different. Furthermore, healthy ageing’s predictability appears to strongly differ from that of Parkinson’s disease, but much less from that of patients with Alzheimer’s disease.