Is it important to take the co-occurrence of obesity and cigarette smoking into account in brain imaging studies in major depressive disorder?

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Delibas D. H., Zorlu P. K., Baskin E. P., BORA İ. E., Adibelli Z. H., Zorlu N.

DUSUNEN ADAM-JOURNAL OF PSYCHIATRY AND NEUROLOGICAL SCIENCES, cilt.32, sa.2, ss.121-128, 2019 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 2
  • Basım Tarihi: 2019
  • Doi Numarası: 10.14744/dajpns.2019.00018
  • Dergi Adı: DUSUNEN ADAM-JOURNAL OF PSYCHIATRY AND NEUROLOGICAL SCIENCES
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.121-128
  • Anahtar Kelimeler: Cortical thickness, major depressive disorder, structural imaging, subcortical volume, REDUCED CORTICAL THICKNESS, SURFACE-BASED ANALYSIS, BODY-MASS INDEX, 1ST EPISODE, SUBCORTICAL VOLUME, FAMILIAL RISK, WHITE-MATTER, DRUG-NAIVE, METAANALYSIS, ABNORMALITIES
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Objective: To date, a small number of studies have investigated cortical thickness, cortical surface area, and subcortical volume abnormalities in first-episode, untreated patients with Major Depressive Disorder (MDD). The findings of previous studies are not entirely consistent. Previous studies did not match first-episode, untreated patients with MDD to controls regarding body mass index (BMI) and smoking, which could contribute to the inconsistency of results. The aim of the current study was to examine whether morphological abnormalities are present in first-episode and untreated MDD patients in comparison with well-matched controls, particularly concerning BMI and smoking status.