Common Variable Immunodeficiency Mimicking Systemic-Onset Juvenile Idiopathic Arthritis: Differential Diagnosis

Makay B., Olmez D., Unsal E., Anal O.

TURKIYE KLINIKLERI TIP BILIMLERI DERGISI, cilt.29, sa.3, ss.775-777, 2009 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 3
  • Basım Tarihi: 2009
  • Dergi Adı: TURKIYE KLINIKLERI TIP BILIMLERI DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.775-777
  • Anahtar Kelimeler: Arthritis, hypogammaglobulinemia, common variable immunodeficiency
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Primary immune deficiencies are a group of genetic disorders in which one or more components of the immune system are lacking or dysfunctional. Dysregulation in the immune response may lead to bone and joint abnormalities in patients with primary immune dificiencies, with arthritis being the most common. Common variable immunodeficiency is the most common symptomatic primary antibody deficiency syndrome. In this report, a male patient was described who presented with arhritis, intermittant fever and hepatosplenomegaly mimicking systemic onset juvenile idiopathic arthritis and finally was diagnosed with common variable immunodeficiency. This case suggested that serum immunoglobulin levels should be screened in patients with suspected juvenil idiopathic arthritis in order to rule out immunodeficiency states.