Antithrombin III pretreatment reduces neutrophil recruitment into the lung and skeletal muscle tissues in the rat model of bilateral lower limb ischemia and reperfusion: a pilot study.

Duru S., Koca U., Oztekin S., Olguner Ç. G., Kar A., Coker C., ...More

Acta anaesthesiologica Scandinavica, vol.49, no.8, pp.1142-8, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 49 Issue: 8
  • Publication Date: 2005
  • Doi Number: 10.1111/j.1399-6576.2005.00764.x
  • Journal Name: Acta anaesthesiologica Scandinavica
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1142-8
  • Keywords: activated leukocytes, anti-inflammatory, antithrombin III, ischemia-reperfusion, myeloperoxidase, prostacyclin, TUMOR-NECROSIS-FACTOR, SYSTEMIC INFLAMMATORY RESPONSE, LOWER TORSO ISCHEMIA, FACTOR-ALPHA, INJURY, ENDOTOXIN, MYELOPEROXIDASE, INTERLEUKIN-1, SELECTIN, SHOCK
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background: Anti-inflammatory action of Antithrombin III (AT III) is still not well understood in ischemia/reperfusion (I/R) injury. In the present study, we aimed to investigate the anti-inflammatory action of AT III on remote lung and local skeletal muscle tissue injury in a rat model of bilateral lower limb I/R model.