Antithrombin III pretreatment reduces neutrophil recruitment into the lung and skeletal muscle tissues in the rat model of bilateral lower limb ischemia and reperfusion: a pilot study.

Duru, S; Koca, U; Oztekin, S; Olguner, ÇİMEN; Kar, A; Coker, ŞADİYE; Ulukus, EMİNE; Tasci, C; Elar, Z

doi:10.1111/j.1399-6576.2005.00764.x

Antithrombin III pretreatment reduces neutrophil recruitment into the lung and skeletal muscle tissues in the rat model of bilateral lower limb ischemia and reperfusion: a pilot study.

Duru S., Koca U., Oztekin S., Olguner Ç. G., Kar A., Coker C., ...More

Acta anaesthesiologica Scandinavica, vol.49, no.8, pp.1142-8, 2005 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 49 Issue: 8
Publication Date: 2005
Doi Number: 10.1111/j.1399-6576.2005.00764.x
Journal Name: Acta anaesthesiologica Scandinavica
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.1142-8
Keywords: activated leukocytes, anti-inflammatory, antithrombin III, ischemia-reperfusion, myeloperoxidase, prostacyclin
Dokuz Eylül University Affiliated: Yes

Abstract

Background: Anti-inflammatory action of Antithrombin III (AT III) is still not well understood in ischemia/reperfusion (I/R) injury. In the present study, we aimed to investigate the anti-inflammatory action of AT III on remote lung and local skeletal muscle tissue injury in a rat model of bilateral lower limb I/R model.