Does tibolone affect serum leptin levels and body weight in postmenopausal women?

GÖL M., ÖZŞENER S., ŞENDAĞ F., Uretmen S., Oztekin K., Tanyalcin T., ...More

Archives of Gynecology and Obstetrics, vol.272, no.2, pp.127-130, 2005 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 272 Issue: 2
  • Publication Date: 2005
  • Doi Number: 10.1007/s00404-004-0686-y
  • Journal Name: Archives of Gynecology and Obstetrics
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.127-130
  • Keywords: Body mass index, Leptin, Tibolone
  • Dokuz Eylül University Affiliated: Yes


Objectives: Leptin has a significant role in body weight regulation and energy balance. We examined the effect of tibolone on the body weight and serum leptin levels in postmenopausal women. Study design: Twenty women (aged 43-60 years) participated in this prospective study. All women in this study protocol received 2.5 mg/day of tibolone. Absolute and body mass index (BMI)-corrected serum leptin concentrations and BMI values were measured at baseline, after 3 months, and after 6 months of the tibolone therapy. Results: Tibolone did not affect absolute and BMI-corrected serum leptin levels, and BMI values during the treatment. A significant linear correlation between BMI values and serum leptin levels was observed (p<0.05, r=0.67). Conclusions: Tibolone seems not to affect serum leptin levels, body weight and BMI values of postmenopausal women. There is a significant correlation between serum leptin levels and BMI values. © Springer-Verlag 2004.