Akademik Veri Yönetim Sistemi
JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES, cilt.7, sa.1, ss.196-213, 2023 (ESCI)
Purpose: Determination of proteomic differences plays an important role in biomarker investigations. Due
to its heterogenic molecular background, identification of certain biomarkers is still a demand both for
diagnosis and prognosis of neuroblastoma. In this study, it is aimed to identify marker
proteins/mechanisms that may play role in neuroblastoma prognosis.
Material and Methods: Real-time PCR analyses were performed for 2p24.3, 11q23, 1p36 and 17q25
status from tumor samples of the patients to determine the risk groups. A proteomic approach was used
for different risk groups of the disease by using matrix-assisted laser desorption ionization–time of flight
(MALDI-TOF/TOF) approach. Mononuclear cell pools from blood samples of patients for different risk
groups were constructed and protein expression changes for different groups were identified.
Results: Manganese-superoxide dismutase (SOD2) protein was found to significantly increase in highrisk group of neuroblastoma patients.
Conclusion: Our results showed that SOD2 may play an important role in neuroblastoma progression
and be a candidate prognostic peripheral blood marker for neuroblastoma patients.