Long-Term Efficacy Results of EORTC Genito-Urinary Group Randomized Phase 3 Study 30911 Comparing Intravesical Instillations of Epirubicin, Bacillus Calmette-Guerin, and Bacillus Calmette-Guerin plus Isoniazid in Patients with Intermediate- and High-Risk Stage Ta T1 Urothelial Carcinoma of the Bladder

Sylvester, Richard; Brausi, Maurizio; Kirkels, Wim; Hoeltl, Wolfgang; Da Silva, Fernando; Powell, Philip; Prescott, Stephen; Kirkali, Ziya; van de Beek, Cees; Gorlia, Thierry; de Reijke, Theo

doi:10.1016/j.eururo.2009.12.024

Long-Term Efficacy Results of EORTC Genito-Urinary Group Randomized Phase 3 Study 30911 Comparing Intravesical Instillations of Epirubicin, Bacillus Calmette-Guerin, and Bacillus Calmette-Guerin plus Isoniazid in Patients with Intermediate- and High-Risk Stage Ta T1 Urothelial Carcinoma of the Bladder

Atıf İçin Kopyala

Sylvester R. J., Brausi M. A., Kirkels W. J., Hoeltl W., Da Silva F. C., Powell P. H., ...Daha Fazla

EUROPEAN UROLOGY, cilt.57, sa.5, ss.766-773, 2010 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 57 Sayı: 5
Basım Tarihi: 2010
Doi Numarası: 10.1016/j.eururo.2009.12.024
Dergi Adı: EUROPEAN UROLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.766-773
Anahtar Kelimeler: Bacillus Calmette-Guerin, Epirubicin, Instillation therapy, Isoniazid, Non-muscle-invasive bladder cancer, Randomized clinical trial, Urothelial carcinoma of the bladder, MITOMYCIN-C, CLINICAL-TRIALS, EUROPEAN ORGANIZATION, FORMAL METAANALYSIS, III TRIAL, CANCER, CHEMOTHERAPY, PROGRESSION, RECURRENCE
Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background: Intravesical chemotherapy and bacillus Calmette-Guerin (BCG) reduce the recurrence rate in patients with stage Ta T1 urothelial bladder cancer; however, the benefit of BCG relative to chemotherapy for long-term end points is controversial, especially in intermediate-risk patients.