Tc-99m-MIBI scintigraphy in metastatic renal cell carcinoma: Clinical validation of the relationship between Tc-99m-MIBI uptake and P-glycoprotein expression in tumour tissue

Derebek E., Kirkali Z., Dogan A., Degirmenci B., Yilmaz M., Igci E., ...Daha Fazla

EUROPEAN JOURNAL OF NUCLEAR MEDICINE, cilt.23, sa.8, ss.976-979, 1996 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 8
  • Basım Tarihi: 1996
  • Doi Numarası: 10.1007/bf01084374
  • Dergi Adı: EUROPEAN JOURNAL OF NUCLEAR MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.976-979
  • Anahtar Kelimeler: technetium-99m, hexakis-2-methoxyisobutylisonitrile, P-glycoprotein, renal cell carcinoma, multidrug resistance, INTRINSIC DRUG-RESISTANCE, MULTIDRUG-RESISTANCE, CANCER, RNA
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

Technetium-99m hexakis-2-methoxyisobutylisonitrile (MIBI) and thallium-201 imaging was performed in a patient with metastatic renal cell carcinoma (RCC), which is a well-known tumour type demonstrating P1-glycoprotein (PGP) overexpression, Two scintigraphic patterns - TI(+)/MIBI(-) in primary tumour and TI(+)/MIBI(+) in metastatic tumour - were observed, suggesting high- and low-level PGP expression, respectively, Immunochemical study for PGP revealed strong staining of the primary tumour cells, This case clinically validates the previously suggested relationship between Tc-99m-MIBI uptake and PGP expression.