Tc-99m-MIBI scintigraphy in metastatic renal cell carcinoma: Clinical validation of the relationship between Tc-99m-MIBI uptake and P-glycoprotein expression in tumour tissue

Derebek E., Kirkali Z., Dogan A., Degirmenci B., Yilmaz M., Igci E., ...More

EUROPEAN JOURNAL OF NUCLEAR MEDICINE, vol.23, no.8, pp.976-979, 1996 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 8
  • Publication Date: 1996
  • Doi Number: 10.1007/bf01084374
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.976-979
  • Keywords: technetium-99m, hexakis-2-methoxyisobutylisonitrile, P-glycoprotein, renal cell carcinoma, multidrug resistance, INTRINSIC DRUG-RESISTANCE, MULTIDRUG-RESISTANCE, CANCER, RNA
  • Dokuz Eylül University Affiliated: No


Technetium-99m hexakis-2-methoxyisobutylisonitrile (MIBI) and thallium-201 imaging was performed in a patient with metastatic renal cell carcinoma (RCC), which is a well-known tumour type demonstrating P1-glycoprotein (PGP) overexpression, Two scintigraphic patterns - TI(+)/MIBI(-) in primary tumour and TI(+)/MIBI(+) in metastatic tumour - were observed, suggesting high- and low-level PGP expression, respectively, Immunochemical study for PGP revealed strong staining of the primary tumour cells, This case clinically validates the previously suggested relationship between Tc-99m-MIBI uptake and PGP expression.