Nano/Microcellulose-Doped Textile-Based Carboxymethyl Chitosan-Polyethylene Glycol Hydrogels For Surgical Dressings


TÜRKOĞLU G. C., ZİYLAN A., KARAVANA S. Y., AYDIN KÖSE F., ÖNDER T., ERDOĞAN Ü. H., ...More

XVth International Izmir Textile and Apparel Symposium - IITAS 2021, İzmir, Turkey, 26 - 28 October 2021, pp.397-403

  • Publication Type: Conference Paper / Full Text
  • City: İzmir
  • Country: Turkey
  • Page Numbers: pp.397-403
  • Dokuz Eylül University Affiliated: Yes

Abstract

In this study, soft hydrogel layers reinforced with cotton nonwoven were produced to use as a surgical dressing. Solution consisting of two polymers (O-carboxymethyl chitosan and polyethylene glycol) were chemically cross-linked using polyethylene glycol diglycidyl ether. Optimum hydrogel formulation was determined considering mechanical parameters. After casting of the selected formulation onto nonwovens, samples were freeze-dried. To increase the swelling capacity of the hydrogels, nano/micro-sized cellulose was added. Physical features, dynamic fluid handling capacity, water vapor permeability, morphology (SEM), and chemical structure (FT-IR) were examined. Antibacterial and in vitro cytotoxicity assays were applied to the formulation showing the best characteristics.