Akademik Veri Yönetim Sistemi
Anestezi Dergisi, cilt.16, sa.1, ss.22-28, 2008 (Scopus, TRDizin)
Objective: To examine the role of ephedrine on the effects of convulsion thresholds caused by toxic doses of bupivacaine. Methods: 21 pregnant rabbits were included in this study. On the first day of the study, sockets were placed on both hemispheres of all rabbits for monitoring the EEG signals. On the second day, the awake spontaneously breathing animals were divided into three groups randomly. Group 1 (n=7) was given 1.5 mg kg-1 min-1 of bupivacaine; Group 2 (n=7) was given 1.5 mg kg-1 min-1 of bupivacaine with 50 μg kg-1 min-1 of ephedrine sulfate; and Group 3 (n=7) was given 1.5 mg kg-1 min-1 of bupivacaine with 100 μg kg-1 min-1 of ephedrine sulfate as intravenous infusions. The time to appearance of spikes, the total drug doses with serum glucose, Na+ and K+ levels were measured at baseline, at the time of first EEG spike appearance and at 5 minutes later. Results: The spike times were measured as 31.30, 24.53 and 10.37 sec in Group 1, 2 and 3 respectively and the differences among them were statistically significant (p<0.01). Total bupivacaine doses were 2.28, 1.6 and 0.7 mg in the groups respectively and the difference between the groups were significant (p<0.01). There were no differences in total ephedrine doses between the groups. Conclusion: The result of our study showed that ephedrine decreases the threshold of convulsion in pregnant rabbits receiving toxic doses of bupivacaine.