The involvement of Nrf2-mediated antioxidant defense in neurovascular protection by activated protein C


Genc K.

Bioscience Hypotheses, cilt.2, sa.3, ss.188-189, 2009 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 2 Sayı: 3
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1016/j.bihy.2008.09.007
  • Dergi Adı: Bioscience Hypotheses
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.188-189
  • Anahtar Kelimeler: Activated protein C, Blood-brain barrier, Neuroprotection, Nrf2, Oxidative stress
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

The natural anticoagulant protein, activated protein C, is neuroprotective and vascular protective, however, the precise mechanisms of its beneficial effect against neurovascular injury are not entirely known. Activated protein C may modulate antioxidant defense system at the transcriptional level. © 2009 Elsevier Ltd. All rights reserved.