The effects of PPAR gamma agonist rosiglitazone on neointimal hyperplasia in rabbit carotid anastomosis model
JOURNAL OF CARDIOTHORACIC SURGERY, cilt.7, 2012 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 7
- Basım Tarihi: 2012
- Doi Numarası: 10.1186/1749-8090-7-57
- Dergi Adı: JOURNAL OF CARDIOTHORACIC SURGERY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Anahtar Kelimeler: Neointima, Rosiglitazone, Matrix metalloproteinases (MMPs), Rabbit
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Dokuz Eylül Üniversitesi Adresli: Evet
Özet
Background: Neointimal hyperplasia involving smooth muscle cell (SMC) proliferation, migration and extracellular matrix (ECM) degradation is an important component of atherosclerosis. It develops as a response to vascular injury after balloon angioplasty and vascular graft placement. Matrix metalloproteinases (MMPs) induce SMC proliferation, migration and contribute to intimal hyperplasia by degrading ECM. PPAR. agonists inhibit SMC proliferation, migration and lesion formation. In this study, we aimed to investigate the effects of PPAR. agonist rosiglitazone on neointimal hyperplasia and gelatinase (MMP-2 and MMP-9) expressions in rabbit carotid anastomosis model.