Trospium and cognition in patients with Late Onset Alzheimer Disease

IŞIK A. T., Celik T., Bozoglu E., Doruk H.

JOURNAL OF NUTRITION HEALTH & AGING, vol.13, no.8, pp.672-676, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 8
  • Publication Date: 2009
  • Doi Number: 10.1007/s12603-009-0196-5
  • Journal Name: JOURNAL OF NUTRITION HEALTH & AGING
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.672-676
  • Keywords: Alzheimer's disease, urge incontinence, trospium, galantamine, elderly, PHASE-III TRIAL, OVERACTIVE BLADDER, CHOLINESTERASE-INHIBITORS, MANAGEMENT, CHLORIDE, ANTICHOLINERGICS, INCONTINENCE, PREVALENCE, SYMPTOMS, DEMENTIA
  • Dokuz Eylül University Affiliated: No

Abstract

Cholinesterase inhibitors for the treatment of Alzheimer's Disease (AD) and antimuscarinic agents for the treatment of urge urinary incontinence (UUI) may reduce the potential effect of each other in the patients with both diseases. Trospium has a relatively low lipophilicity and low CNS penetration, and galantamine, a cholinesterase inhibitors, has also allosterically modulates nicotinic cholinergic receptors. This study was designed to evaluate the effects of dual use of trospium and galantamine for 6 months in the elderly patients with AD and UUI.