Evaluation of periostin and factors associated with new bone formation in ankylosing spondylitis: Periostin may be associated with the Wnt pathway

Solmaz, DİLEK; Uslu, SADETTİN; Kozaci, Didem; Karaca, Neslihan; Bulbul, Hale; Tarhan, Emine; ÖZMEN, MUSTAFA; Can, GERÇEK; AKAR, SERVET

doi:10.1111/1756-185x.13186

Evaluation of periostin and factors associated with new bone formation in ankylosing spondylitis: Periostin may be associated with the Wnt pathway

Solmaz D., Uslu S., Kozaci D., Karaca N., Bulbul H., Tarhan E. F., ...Daha Fazla

INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, cilt.21, sa.2, ss.502-509, 2018 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 21 Sayı: 2
Basım Tarihi: 2018
Doi Numarası: 10.1111/1756-185x.13186
Dergi Adı: INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.502-509
Anahtar Kelimeler: spondyloarthritis, outcome measures, ankylosing spondylitis, POSTN protein, Wnt signaling pathway
Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Objective: Periostin has been shown to be involved in bone anabolism through the regulation of Wnt-beta-catenin signaling. It may be one of the pathogenic mechanisms in syndesmophyte formation in ankylosing spondylitis (AS). The aim of this study was to evaluate serum periostin levels in patients with AS and to assess relationships among biomarkers of bone formation and periostin in disease outcomes, particularly radiographic changes.