Effect of Levosimendan in Patients with Severe Systolic Heart Failure and Worsening Renal Function

ZORLU A., YÜCEL H., Yontar O. C., Karahan O., TANDOĞAN İ., KATRANCIOĞLU N., ...More

ARQUIVOS BRASILEIROS DE CARDIOLOGIA, vol.98, no.6, pp.537-543, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 98 Issue: 6
  • Publication Date: 2012
  • Doi Number: 10.1590/s0066-782x2012005000048
  • Journal Name: ARQUIVOS BRASILEIROS DE CARDIOLOGIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.537-543
  • Keywords: Heart failure, levosimendan, worsening renal function, renal-enhancing effect, creatinine, glomerular filtration rate, RIGHT-VENTRICULAR FUNCTION, CALCIUM SENSITIZER, DOBUTAMINE, OUTCOMES, IMPACT
  • Dokuz Eylül University Affiliated: No

Abstract

Background: Levosimendan, a calcium sensitizer, increases the sensitivity of the heart to calcium, thus increasing myocardial contractility without a rise in intracellular calcium. It was recently shown that levosimendan is beneficial in improving renal function. However, it remains to be established that the beneficial effect is differentially related to renal status during index event.