Effect of Levosimendan in Patients with Severe Systolic Heart Failure and Worsening Renal Function

ZORLU A., YÜCEL H., Yontar O. C., Karahan O., TANDOĞAN İ., KATRANCIOĞLU N., ...Daha Fazla

ARQUIVOS BRASILEIROS DE CARDIOLOGIA, cilt.98, sa.6, ss.537-543, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 98 Sayı: 6
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1590/s0066-782x2012005000048
  • Dergi Adı: ARQUIVOS BRASILEIROS DE CARDIOLOGIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.537-543
  • Anahtar Kelimeler: Heart failure, levosimendan, worsening renal function, renal-enhancing effect, creatinine, glomerular filtration rate, RIGHT-VENTRICULAR FUNCTION, CALCIUM SENSITIZER, DOBUTAMINE, OUTCOMES, IMPACT
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

Background: Levosimendan, a calcium sensitizer, increases the sensitivity of the heart to calcium, thus increasing myocardial contractility without a rise in intracellular calcium. It was recently shown that levosimendan is beneficial in improving renal function. However, it remains to be established that the beneficial effect is differentially related to renal status during index event.