Effect of Levosimendan in Patients with Severe Systolic Heart Failure and Worsening Renal Function
ARQUIVOS BRASILEIROS DE CARDIOLOGIA, vol.98, no.6, pp.537-543, 2012 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 98 Issue: 6
- Publication Date: 2012
- Doi Number: 10.1590/s0066-782x2012005000048
- Journal Name: ARQUIVOS BRASILEIROS DE CARDIOLOGIA
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.537-543
- Keywords: Heart failure, levosimendan, worsening renal function, renal-enhancing effect, creatinine, glomerular filtration rate
- Dokuz Eylül University Affiliated: No
Abstract
Background: Levosimendan, a calcium sensitizer, increases the sensitivity of the heart to calcium, thus increasing myocardial contractility without a rise in intracellular calcium. It was recently shown that levosimendan is beneficial in improving renal function. However, it remains to be established that the beneficial effect is differentially related to renal status during index event.