Biomarkers and cytokines of bone turnover: extensive evaluation in a cohort of patients with ankylosing spondylitis

Taylan, Ali; SARI, İSMAİL; AKINCI, BARIŞ; Bilge, Safak; Kozaci, Didem; Akar, Servet; Colak, Ayfer; Yalcin, Hulya; Gunay, Necati; Akkoc, Nurullah

doi:10.1186/1471-2474-13-191

Biomarkers and cytokines of bone turnover: extensive evaluation in a cohort of patients with ankylosing spondylitis

Taylan A., SARI İ., AKINCI B., Bilge S., Kozaci D., Akar S., ...Daha Fazla

BMC MUSCULOSKELETAL DISORDERS, cilt.13, 2012 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 13
Basım Tarihi: 2012
Doi Numarası: 10.1186/1471-2474-13-191
Dergi Adı: BMC MUSCULOSKELETAL DISORDERS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Anahtar Kelimeler: Ankylosing spondylitis, Bone mineral density, OPG, RANKL, DKK-1
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background: Ankylosing spondylitis (AS) is a chronic inflammatory disease of spine and sacroiliac joints; it is characterized by new bone formation, and the disease processes can be accompanied by osteoporosis. In the present study, we investigated changes in bone mineral density (BMD) and in the levels of various bone turnover-related biomarkers and cytokines in a cohort of AS patients, with regard to clinical parameters, disease activity, and treatment regimen.