Biomarkers and cytokines of bone turnover: extensive evaluation in a cohort of patients with ankylosing spondylitis


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Taylan A., SARI İ., AKINCI B., Bilge S., Kozaci D., Akar S., ...More

BMC MUSCULOSKELETAL DISORDERS, vol.13, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13
  • Publication Date: 2012
  • Doi Number: 10.1186/1471-2474-13-191
  • Journal Name: BMC MUSCULOSKELETAL DISORDERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Ankylosing spondylitis, Bone mineral density, OPG, RANKL, DKK-1, RHEUMATOID-ARTHRITIS, BIOCHEMICAL MARKERS, PSORIATIC-ARTHRITIS, RECEPTOR ACTIVATOR, MINERAL DENSITY, SERUM-LEVELS, BATH, DISEASE, RESORPTION
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background: Ankylosing spondylitis (AS) is a chronic inflammatory disease of spine and sacroiliac joints; it is characterized by new bone formation, and the disease processes can be accompanied by osteoporosis. In the present study, we investigated changes in bone mineral density (BMD) and in the levels of various bone turnover-related biomarkers and cytokines in a cohort of AS patients, with regard to clinical parameters, disease activity, and treatment regimen.