Biomarkers and cytokines of bone turnover: extensive evaluation in a cohort of patients with ankylosing spondylitis

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Taylan A., SARI İ., AKINCI B., Bilge S., Kozaci D., Akar S., ...Daha Fazla

BMC MUSCULOSKELETAL DISORDERS, cilt.13, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1186/1471-2474-13-191
  • Dergi Adı: BMC MUSCULOSKELETAL DISORDERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Ankylosing spondylitis, Bone mineral density, OPG, RANKL, DKK-1, RHEUMATOID-ARTHRITIS, BIOCHEMICAL MARKERS, PSORIATIC-ARTHRITIS, RECEPTOR ACTIVATOR, MINERAL DENSITY, SERUM-LEVELS, BATH, DISEASE, RESORPTION
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background: Ankylosing spondylitis (AS) is a chronic inflammatory disease of spine and sacroiliac joints; it is characterized by new bone formation, and the disease processes can be accompanied by osteoporosis. In the present study, we investigated changes in bone mineral density (BMD) and in the levels of various bone turnover-related biomarkers and cytokines in a cohort of AS patients, with regard to clinical parameters, disease activity, and treatment regimen.