Biomarkers and cytokines of bone turnover: extensive evaluation in a cohort of patients with ankylosing spondylitis
BMC MUSCULOSKELETAL DISORDERS, vol.13, 2012 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 13
- Publication Date: 2012
- Doi Number: 10.1186/1471-2474-13-191
- Journal Name: BMC MUSCULOSKELETAL DISORDERS
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Keywords: Ankylosing spondylitis, Bone mineral density, OPG, RANKL, DKK-1
- Open Archive Collection: AVESIS Open Access Collection
- Dokuz Eylül University Affiliated: Yes
Abstract
Background: Ankylosing spondylitis (AS) is a chronic inflammatory disease of spine and sacroiliac joints; it is characterized by new bone formation, and the disease processes can be accompanied by osteoporosis. In the present study, we investigated changes in bone mineral density (BMD) and in the levels of various bone turnover-related biomarkers and cytokines in a cohort of AS patients, with regard to clinical parameters, disease activity, and treatment regimen.