Effect of N-acetylcysteine on intimal hyperplasia and endothelial proliferation in rabbit carotid artery anastomosis

Kavala A. A., Kuserli Y., Turkyilmaz S.

ARCHIVES OF MEDICAL SCIENCE, cilt.15, sa.6, ss.1576-1581, 2019 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 6
  • Basım Tarihi: 2019
  • Doi Numarası: 10.5114/aoms.2018.77769
  • Dergi Adı: ARCHIVES OF MEDICAL SCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1576-1581
  • Anahtar Kelimeler: N-acetylcysteine, intimal hyperplasia, endothelial proliferation, carotid artery
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

Introduction: Neointimal hyperplasia due to smooth muscle cell migration and proliferation, as well as extracellular matrix accumulation, plays an important role in stenosis and restenosis that develop after reconstructive vascular interventions. Various agents are being tested to reduce neointimal hyperplasia and to prevent lumen stenosis. In the present study, the effect of N-acetylcysteine (NAC) on intimal hyperplasia and endothelial hyperplasia after carotid anastomosis was investigated in a rabbit model.