Effect of N-acetylcysteine on intimal hyperplasia and endothelial proliferation in rabbit carotid artery anastomosis

Kavala A. A., Kuserli Y., Turkyilmaz S.

ARCHIVES OF MEDICAL SCIENCE, vol.15, no.6, pp.1576-1581, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 6
  • Publication Date: 2019
  • Doi Number: 10.5114/aoms.2018.77769
  • Journal Name: ARCHIVES OF MEDICAL SCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1576-1581
  • Keywords: N-acetylcysteine, intimal hyperplasia, endothelial proliferation, carotid artery
  • Dokuz Eylül University Affiliated: No

Abstract

Introduction: Neointimal hyperplasia due to smooth muscle cell migration and proliferation, as well as extracellular matrix accumulation, plays an important role in stenosis and restenosis that develop after reconstructive vascular interventions. Various agents are being tested to reduce neointimal hyperplasia and to prevent lumen stenosis. In the present study, the effect of N-acetylcysteine (NAC) on intimal hyperplasia and endothelial hyperplasia after carotid anastomosis was investigated in a rabbit model.