Benchmark of thirteen bioinformatic pipelines for metagenomic virus diagnostics using datasets from clinical samples.

de Vries J. J. C., Brown J. R., Fischer N., Sidorov I. A., Morfopoulou S., Huang J., ...More

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, vol.141, pp.104908, 2021 (SCI-Expanded) identifier identifier identifier


Introduction: Metagenomic sequencing is increasingly being used in clinical settings for difficult to diagnose cases. The performance of viral metagenomic protocols relies to a large extent on the bioinformatic analysis. In this study, the European Society for Clinical Virology (ESCV) Network on NGS (ENNGS) initiated a benchmark of metagenomic pipelines currently used in clinical virological laboratories.