Preparation of a Tc-99m-labeled graft polymer and its in vitro and in vivo evaluation
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, vol.329, no.2, pp.511-525, 2021 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 329 Issue: 2
- Publication Date: 2021
- Doi Number: 10.1007/s10967-021-07817-6
- Journal Name: JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Analytical Abstracts, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Chimica, Communication Abstracts, EMBASE, Food Science & Technology Abstracts, INSPEC, Metadex, Pollution Abstracts, Public Affairs Index, Veterinary Science Database, Civil Engineering Abstracts
- Page Numbers: pp.511-525
- Keywords: Nanopolymer, Graft Polymer, Cytotoxicity, Tc-99m, Radiolabeling, Proline
- Dokuz Eylül University Affiliated: Yes
Abstract
The aim of this study is the synthesis of a novel Tc-99m-labeld graft polymer and the biological evaluation of its in vitro and in vivo properties. To this end, a L-proline-graft-poly(HEMA) was prepared and labeled with Tc-99m. The radiochemical yield of approximately the Tc-99m-labeled compound amounted to 97 +/- 2.3%. The cytotoxicity test revealed no cytotoxic effect after a 24- and 48-h incubation. The results of the hemolysis test showed that hemolysis was non-toxic with an effect level of less than 2%. Subsequently, the biodistribution in healthy rats was determined. High accumulation of the polymer was observed in the pancreas, thyroid and prostate.