Ent-kaurene Diterpenoids from Sideritis lycia with Antiviral and Cytotoxic Activities

KILIÇ T., TOPÇU G., GÖREN A. C., Aydogmus Z., Karagoz A., Yildiz Y. K., ...More

RECORDS OF NATURAL PRODUCTS, vol.14, no.4, pp.256-268, 2020 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 4
  • Publication Date: 2020
  • Doi Number: 10.25135/rnp.
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, ABI/INFORM, CAB Abstracts, EMBASE, Veterinary Science Database, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.256-268
  • Keywords: Sideritis lycia, diterpenoid, NMR and mass spectroscopy, antiviral, cytotoxic activity, insecticidal activity, KAURANE DITERPENOIDS, ANTIOXIDANT ACTIVITY, BIOLOGICAL-ACTIVITY, ESSENTIAL OILS, TOXICITY, EXTRACTS, PLANTS, PESTS, L.
  • Dokuz Eylül University Affiliated: Yes


The genus Sideritis (Lamiaceae) is represented by 45 species (54 taxa) in Anatolia with high endemism ratio (74%), and Turkey is one of the gene centers of the genus along with Spain. Acetone extract of the aerial parts of Sideritis lycia afforded eight known ent-kaurene diterpenoids, structures of which have been identified as linearol, isolinearol, isosidol, sidol, siderol, sideridiol, 7-epi-candicandiol and foliol through 1H NMR, 13 C NMR and mass spectroscopic analyses. Cytotoxic and antiviral activities of the acetone extract, linearol, sidol and isosidol were investigated together with insecticidal activity of species. The antiviral index of linearol, isosidol and acetone extract of S. lycia were determined as 2.31, 2.01 and 2.58, respectively, except sidol. 7-Epi-candicandiol was found to be the most active diterpene against a series of cancer cell lines with ED50 values; KB (13.3 mu g/mL), COL-2 (11.8 mu g/mL), LU1 (17.9 mu g/mL), LNCaP (14.9 mu g/mL) and A2780 (9.0 mu g/mL). Activity results of this study indicated that ent-kaurane diterpenes have potential to be considered as antiviral and cytotoxic lead compounds.