Effect of Tadalafil on Neointimal Hyperplasia in a Rabbit Carotid Artery Anastomosis Model

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Guzeloglu M., Aykut K., Albayrak G., Atmaca S., Oktar S., BAĞRIYANIK H. A., ...More

ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY, vol.19, no.6, pp.468-474, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 6
  • Publication Date: 2013
  • Doi Number: 10.5761/atcs.oa.12.02017
  • Journal Name: ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.468-474
  • Keywords: Neointima, tadalafil, nitric oxide, cyclic guanosine monophosphate signaling, rabbit, SMOOTH-MUSCLE-CELLS, PHOSPHODIESTERASE-5 INHIBITION, PROTEIN-KINASE, GRAFT FAILURE, RAT MODEL, PROLIFERATION, INJURY, CGMP, ENDARTERECTOMY, DYSFUNCTION
  • Dokuz Eylül University Affiliated: Yes

Abstract

Purpose: Intimal thickening, which results from the response to arterial damage caused by therapeutic interventions or other reasons, is usually called as neointima. Neointimal hyperplasia is a main step in the pathogenesis of late-term restenosis, which is developed after vascular interventions. Reduction in nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) signaling plays a substantial role in the pathogenesis of neointima formation. Phosphodiesterase V is detected in the peripheral coronary and pulmonary vascular smooth muscle cells and in the cardiac tissue. Based on the effects of phosphodiesterase V inhibitors on vascular smooth muscle cells, in the present study, the effect of tadalafil, a new member of phosphodiesterase V inhibitors, on neointimal hyperplasia was investigated in the rabbit carotid artery anastomosis model.