Effect of Tadalafil on Neointimal Hyperplasia in a Rabbit Carotid Artery Anastomosis Model
ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY, vol.19, no.6, pp.468-474, 2013 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 19 Issue: 6
- Publication Date: 2013
- Doi Number: 10.5761/atcs.oa.12.02017
- Journal Name: ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.468-474
- Keywords: Neointima, tadalafil, nitric oxide, cyclic guanosine monophosphate signaling, rabbit
- Open Archive Collection: AVESIS Open Access Collection
- Dokuz Eylül University Affiliated: Yes
Abstract
Purpose: Intimal thickening, which results from the response to arterial damage caused by therapeutic interventions or other reasons, is usually called as neointima. Neointimal hyperplasia is a main step in the pathogenesis of late-term restenosis, which is developed after vascular interventions. Reduction in nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) signaling plays a substantial role in the pathogenesis of neointima formation. Phosphodiesterase V is detected in the peripheral coronary and pulmonary vascular smooth muscle cells and in the cardiac tissue. Based on the effects of phosphodiesterase V inhibitors on vascular smooth muscle cells, in the present study, the effect of tadalafil, a new member of phosphodiesterase V inhibitors, on neointimal hyperplasia was investigated in the rabbit carotid artery anastomosis model.