Akademik Veri Yönetim Sistemi
8th European Academy of Neurology Congress, Vienna, Avusturya, 25 - 28 Haziran 2022, ss.640
Background and aims: Late-onset multiple sclerosis (LOMS) and early-onset multiple sclerosis (EOMS) are less common, and their prognosis can be different. The aim was to assess and compare cognitive functions between patients with LOMS and EOMS. Methods: Patients with LOMS (initial age≥50 years) (n=32) and age-, gender-, and type of MS-matched patients with EOMS (initial age between 15–18 years) (n=125) were assessed with the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) battery which included the Symbol Digit Modalities Test (SDMT), the California Verbal Learning Test-2 (CVLT2) and the Brief Visuospatial Memory Test-Revised (BVMT-R). The upper extremity function was assessed using the 9 Hole Peg Test (9DPT), Timed 25-Foot Walk Test (T25FW), and Timed up Go (TUG) was used to assess lower extremity function were evaluated. Results: There was no significant difference in disease duration between the two groups. The EDSS score and age were higher in the LOMS group (2.90±2.07 and 60.25±5.42, respectively) compared with EOMS (1.33±1.83 and 25.76±8.98, respectively). Covariates included age and the EDSS score. There was no significant difference between the groups regarding T25FW, TUG, 9HPT, and BICAMS (p>0.05). Conclusion: The cognitive, upper, and lower extremity functions were similar in the two groups. Considering that distribution of gender and the disease durations were similar; these results suggest that the prognosis of EOMS may be worse than expected. Disclosure: Nothing to disclose.