Dexamethasone-loaded chitosan-based genipin-cross-linked hydrogel for prevention of cisplatin induced ototoxicity in Guinea pig model

Aslier, Nesibe; Altınışık Tağaç, AYLİN; Mungan Durankaya, SERPİL; Calisir, Meryem; Ersoy, Nevin; Kırkım, GÜNAY; Yurdakoc, MEHMET; Bağrıyanık, HÜSNÜ; Yılmaz, OSMAN; Sütay, SEMİH; Güneri, ENİS

doi:10.1016/j.ijporl.2019.04.003

Dexamethasone-loaded chitosan-based genipin-cross-linked hydrogel for prevention of cisplatin induced ototoxicity in Guinea pig model

Aslier N. G. Y., Altınışık Tağaç A., Mungan Durankaya S., Calisir M., Ersoy N., Kırkım G., ...Daha Fazla

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, cilt.122, ss.60-69, 2019 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 122
Basım Tarihi: 2019
Doi Numarası: 10.1016/j.ijporl.2019.04.003
Dergi Adı: INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.60-69
Anahtar Kelimeler: Cisplatin, Dexamethasone, Genipin, Guinea pig, Hydrogel, Ototoxicity
Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Objectives: The aim of this study was to investigate the protective effects of a sustained release form of dexamethasone (dex) loaded chitosan-based genipin-cross-linked hydrogel (CBGCH) in a guinea pig model of cisplatin (CP) induced hearing loss.