Decrease in cell proliferation by an matrix metalloproteinase inhibitor, doxycycline, in a model of immune-complex nephritis


Saglam F., Celik A., Tayfur D., ÇAVDAR Z., YILMAZ O., SARIOĞLU S., ...More

NEPHROLOGY, vol.15, no.5, pp.560-567, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 5
  • Publication Date: 2010
  • Doi Number: 10.1111/j.1440-1797.2010.01289.x
  • Journal Name: NEPHROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.560-567
  • Keywords: doxycycline, extracellular matrix, glomerulonephritis, immune complexes, matrix metalloproteinase, EXTRACELLULAR-MATRIX, ENHANCED EXPRESSION, TISSUE INHIBITORS, GLOMERULONEPHRITIS, NEPHROPATHY, MATRIX-METALLOPROTEINASE-9, TGF-BETA-1, RAT
  • Dokuz Eylül University Affiliated: Yes

Abstract

Aim: Renal expression of matrix metalloproteinases (MMP) and tissue inhibitors of MMP (TIMP) contribute to the development of tubulointerstitial fibrosis characteristic of progressive forms of primary glomerulonephritis (GN). The aim of this study was to investigate the therapeutic effect of MMP inhibitor, doxycycline, administration in an experimental rat model of immune-complex nephritis (ICN).