Role of epigenetic regulatory mechanisms in neonatal hypoxic-ischemic brain injury.

KUMRAL A., Tuzun F., Yesilirmak D., DUMAN N., ÖZKAN H.

Medical hypotheses, cilt.72, sa.6, ss.692-3, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 72 Sayı: 6
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1016/j.mehy.2008.10.032
  • Dergi Adı: Medical hypotheses
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.692-3
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Hypoxic-ischemic brain injury is an important cause of neonatal mortality and subsequent serious neurological sequel. in neonatal brain the severity of hypoxic injury varies most probably due to the effects of multiple protective or deleterious factors. But the mechanisms under this difference are still not full understood. In recent years, some evidence has been found supporting the involvement of epigenetic mechanisms in many neurodegenerative diseases and stroke. We hypothesised that epigenetic mechanisms have been also involved in neonatal hypoxic-ischemic brain injury possibly by suppression of ischemia-induced cerebral inflammation and changing the expression of proapoptotic-antiapoptotic genes. (C) 2009 Elsevier Ltd. All rights reserved.