Role of epigenetic regulatory mechanisms in neonatal hypoxic-ischemic brain injury.


KUMRAL A., Tuzun F., Yesilirmak D., DUMAN N., ÖZKAN H.

Medical hypotheses, vol.72, no.6, pp.692-3, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 72 Issue: 6
  • Publication Date: 2009
  • Doi Number: 10.1016/j.mehy.2008.10.032
  • Journal Name: Medical hypotheses
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.692-3
  • Dokuz Eylül University Affiliated: Yes

Abstract

Hypoxic-ischemic brain injury is an important cause of neonatal mortality and subsequent serious neurological sequel. in neonatal brain the severity of hypoxic injury varies most probably due to the effects of multiple protective or deleterious factors. But the mechanisms under this difference are still not full understood. In recent years, some evidence has been found supporting the involvement of epigenetic mechanisms in many neurodegenerative diseases and stroke. We hypothesised that epigenetic mechanisms have been also involved in neonatal hypoxic-ischemic brain injury possibly by suppression of ischemia-induced cerebral inflammation and changing the expression of proapoptotic-antiapoptotic genes. (C) 2009 Elsevier Ltd. All rights reserved.