Akademik Veri Yönetim Sistemi
BMC ORAL HEALTH, cilt.25, ss.1-9, 2025 (SCI-Expanded)
Background Periodontitis arises from dysbiotic subgingival microbiota and an unresolved infammatory response. Annexin A1 (ANXA1), Carbonic Anhydrase I (CA1), and Elongation Factor 1-gamma (EF1-Ɣ) may play a role in periodontal infammation and disease pathogenesis. This study aimed to investigate the levels of these molecules in gingival crevicular fuid (GCF) of individuals with diferent periodontal conditions. Methods GCF samples were collected from 20 patients with Stage III Grade B periodontitis, 20 with Stage III Grade C periodontitis, 19 gingivitis patients, and 21 periodontally healthy individuals. ANXA1, CA1, and EF1-Ɣ levels were measured using ELISA. Results Clinical parameters were signifcantly higher in periodontitis groups compared to gingivitis and healthy groups (p<0.001). GCF EF1-Ɣ total amount difered among groups, with higher levels in gingivitis compared to periodontitis and healthy control groups (p<0.001). Elevated levels of EF1-Ɣ were found in gingivitis compared to Stage III/B and Stage III/C periodontitis (p<0.001). GCF ANXA1 and CA1 levels were similar across study groups (p>0.05). Conclusion Within the limitations of this study, it might be suggested that the decreased levels of EF1-Ɣ in diseased sites of periodontitis and its elevated levels in gingivitis are associated with the pathogenesis of periodontal disease. Keywords Periodontitis, Gingivitis, Gingival crevicular fuid, Annexin-a1, Carbonic anhydrase-1, Elongation factor-1 gamma, Pathogenesis