Serum levels of carboxy-terminal propeptide of Type 1 procollagen do not reflect the severity of nonalcoholic steatohepatitis

Okan A., Tankurt E., Sabuncuoglu D., SONSUZ A., Guener G., Sagol Ö., ...Daha Fazla

TURKIYE KLINIKLERI TIP BILIMLERI DERGISI, cilt.27, sa.1, ss.27-31, 2007 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 1
  • Basım Tarihi: 2007
  • Dergi Adı: TURKIYE KLINIKLERI TIP BILIMLERI DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.27-31
  • Anahtar Kelimeler: procollagen Type 1 carboxy terminal peptide, liver cirrhosis, ALCOHOLIC LIVER-DISEASE, III PROCOLLAGEN, I PROCOLLAGEN, POSTMENOPAUSAL WOMEN, BIOCHEMICAL MARKERS, CHRONIC HEPATITIS, BONE TURNOVER, COLLAGEN, PEPTIDE, FIBROGENESIS
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Objective: High serum levels of carboxy-terminal propeptide of Type 1 procollagen (PICP) were reported in patients with chronic viral hepatitis, alcoholic liver disease and cirrhosis as a marker of liver fibrosis. However, its status in nonalcoholic steatohepatitis (NASH) is uncertain. The aim of this study was to determine serum PICP levels in NASH patients comparing with cirrhotic patients and healthy individuals, and its association with the degree of necroinflammatory activity and fibrosis.