The Effect of Mitochondrial DNA Mutations in Brain Tumors

Erbayraktar Z., Hasimoglu Z., ERBAYRAKTAR R. S.

JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES, cilt.3, sa.2, ss.107-112, 2019 (ESCI) identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 3 Sayı: 2
  • Basım Tarihi: 2019
  • Doi Numarası: 10.30621/jbachs.2019.590
  • Dergi Adı: JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.107-112
  • Anahtar Kelimeler: Brain tumor, mitochondrial DNA, tumorigenesis, OXIDATIVE-PHOSPHORYLATION, COPY NUMBER, STEM-CELLS, CANCER, GLIOBLASTOMA, LOOP, INSTABILITY, COMPLEXES, DELETIONS, GENOME
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Purpose: Brain tumors are a group of diseases in which different genotypes result in different phenotypes at the molecular level. Although there have been a number of studies related to the role of alterations in nuclear genes, such as oncogenes and tumor suppressor genes, in the development of brain tumors, the effects of mitochondrial genes on tumorigenesis have not been well elucidated.