The Effect of Mitochondrial DNA Mutations in Brain Tumors

Erbayraktar Z., Hasimoglu Z., ERBAYRAKTAR R. S.

JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES, vol.3, no.2, pp.107-112, 2019 (ESCI) identifier

  • Publication Type: Article / Review
  • Volume: 3 Issue: 2
  • Publication Date: 2019
  • Doi Number: 10.30621/jbachs.2019.590
  • Journal Name: JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.107-112
  • Keywords: Brain tumor, mitochondrial DNA, tumorigenesis, OXIDATIVE-PHOSPHORYLATION, COPY NUMBER, STEM-CELLS, CANCER, GLIOBLASTOMA, LOOP, INSTABILITY, COMPLEXES, DELETIONS, GENOME
  • Dokuz Eylül University Affiliated: Yes

Abstract

Purpose: Brain tumors are a group of diseases in which different genotypes result in different phenotypes at the molecular level. Although there have been a number of studies related to the role of alterations in nuclear genes, such as oncogenes and tumor suppressor genes, in the development of brain tumors, the effects of mitochondrial genes on tumorigenesis have not been well elucidated.