Spontaneous intestinal perforation after oral ibuprofen treatment of patent ductus arteriosus in two very-low-birthweight infants

Tatli M., Kumral A., Duman N., DEMİR K., Gurcu O., ÖZKAN H.

ACTA PAEDIATRICA, vol.93, no.7, pp.999-1001, 2004 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Editorial Material
  • Volume: 93 Issue: 7
  • Publication Date: 2004
  • Doi Number: 10.1111/j.1651-2227.2004.tb02702.x
  • Journal Name: ACTA PAEDIATRICA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.999-1001
  • Keywords: spontaneous intestinal perforation, ibuprofen, PDA, preterm, PRETERM INFANTS, INDOMETHACIN
  • Dokuz Eylül University Affiliated: Yes


Aim: To discuss intestinal side effects of ibuprofen in the treatment of patent ductus arteriosus, after having observed two cases of spontaneous intestinal perforation following ibuprofen treatment. Methods: Clinical and laboratory records of two preterm infants, who developed intestinal perforation after ibuprofen administration, were evaluated. Results: Gestational ages of infants were 29 wk (male) and 30 wk (female). Both infants developed intestinal perforations without signs of necrotizing enterocolitis. The perforations cured with Penrose drainage alone.