Spontaneous intestinal perforation after oral ibuprofen treatment of patent ductus arteriosus in two very-low-birthweight infants

Tatli M., Kumral A., Duman N., DEMİR K., Gurcu O., ÖZKAN H.

ACTA PAEDIATRICA, cilt.93, sa.7, ss.999-1001, 2004 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Editöre Mektup
  • Cilt numarası: 93 Sayı: 7
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1111/j.1651-2227.2004.tb02702.x
  • Dergi Adı: ACTA PAEDIATRICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.999-1001
  • Anahtar Kelimeler: spontaneous intestinal perforation, ibuprofen, PDA, preterm
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Aim: To discuss intestinal side effects of ibuprofen in the treatment of patent ductus arteriosus, after having observed two cases of spontaneous intestinal perforation following ibuprofen treatment. Methods: Clinical and laboratory records of two preterm infants, who developed intestinal perforation after ibuprofen administration, were evaluated. Results: Gestational ages of infants were 29 wk (male) and 30 wk (female). Both infants developed intestinal perforations without signs of necrotizing enterocolitis. The perforations cured with Penrose drainage alone. Conclusion: Although ibuprofen is a reasonable treatment alternative to indomethacin, randomized controlled trials, which address potential adverse effects including spontaneous intestinal perforation, are needed.