Evaluation of serum inflammatory markers in treatment-resistant manic patients and adequate responder manic patients

Bulut M., Cati S., Gunes M., Kaya M. C., Kaplan I., ÖZKAN M. H.

PSYCHIATRY RESEARCH, cilt.272, ss.73-79, 2019 (SCI-Expanded, SSCI, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 272
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.psychres.2018.12.073
  • Dergi Adı: PSYCHIATRY RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Sayfa Sayıları: ss.73-79
  • Anahtar Kelimeler: Bipolar disorder, Treatment-resistant mania, Inflammation, hsCRP, CEA, WBC
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

Mania is accompanied with immune activation as indicated by increased pro-inflammatory cytokines, acute phase proteins; and carcinoembryonic antigen (CEA) is known to accompany signs of immune-inflammatory responses in bipolar disorder (BD) and medical disorders. In this study, it was aimed to compare high sensitivity C-reactive protein (hsCRP), CEA levels and white blood cells (WBCs) counts in the treatment-resistant BD (Group 3), the treatment-responsive BD patients (Group 2), and the healthy control group (Group 1). The socio-demographic data form, the Young Mania Rating Scale (YMRS), the Hamilton Depression Rating Scale (HDRS), and the Clinical Global Impression Severity of Illness (CGI-S) Scale were applied to the patients. In Group 3, the WBCs counts, and CEA levels were significantly higher than the other two groups. There was a positive correlation between WBCs counts and YMRS and CGI-S scores in all manic patients. There was a positive correlation between CEA levels and YMRS, HDRS and CGI-S in manic patients. This study shows that there is an activation of the immune-inflammatory response system in treatment resistant manic patients; and, WBCs counts and CEA levels are associated with severity of disease in manic patients.