Attenuation of Neuropathic Pain by P2X7 Receptor Antagonist Brilliant Blue G

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Çalış G., Sönmez A., Akkaya E. C., Demirtaş H., Dalkıran B.

ACTA PHYSIOLOGICA, vol.241, no.S733, pp.47, 2025 (SCI-Expanded, Scopus)

  • Publication Type: Article / Abstract
  • Volume: 241 Issue: S733
  • Publication Date: 2025
  • Doi Number: 10.1111/apha.70001
  • Journal Name: ACTA PHYSIOLOGICA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, Food Science & Technology Abstracts, MEDLINE, SportDiscus, Veterinary Science Database
  • Page Numbers: pp.47
  • Open Archive Collection: AVESIS Open Access Collection
  • Dokuz Eylül University Affiliated: Yes

Abstract

There is growing evidence in recent years that pro-inflammatory mediators play a key role in the development of neuropathic pain through central and peripheral sensitization mechanisms. Brilliant Blue G (BBG) is a non-competitive antagonist of the P2X7 receptor, which is exclusively activated by high extracellular ATP concentrations, causing the intense release of pro-inflammatory cytokines. This study aimed to evaluate the effectiveness of BBG following traumatic injury in a peripheral neuropathy model in rat and assess both the sensory and the affective components of neuropathic pain in the chronic process.