An overview of biomolecules, immobilization methods and support materials of biosensors

Asal M., ÖZEN Ö., Sahinler M., Baysal H. T., POLATOĞLU İ.

SENSOR REVIEW, cilt.39, sa.3, ss.377-386, 2019 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 39 Sayı: 3
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1108/sr-04-2018-0084
  • Dergi Adı: SENSOR REVIEW
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.377-386
  • Anahtar Kelimeler: Biomolecule, Biosensors, Biosensor characteristics, Immobilization, Support materials, ENZYME IMMOBILIZATION, AMPEROMETRIC BIOSENSOR, ELECTROCHEMICAL BIOSENSORS, RECOGNITION ELEMENTS, ELECTRON-TRANSFER, CHEMICAL SENSORS, ANTIBODIES, POLYMERS, NANOCOMPOSITES, STABILIZATION
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Purpose Traditional analytical methods are often time-consuming and require bulky instruments, making their widespread implementation challenging. This paper aims to represent the principal concepts of biosensors as an introduction of this technology to readers and offers a comprehensive understanding of its functions. Design/methodology/approach The authors provide descriptions of the components, characteristics and advantages of biosensors along with the immobilization methods, followed by a brief discussion. Findings A biosensor is an analytical device comprising a specific biomolecule and a transducer in conjunction with an output system. The biomolecule recognizes a specific target which leads to a change in physicochemical properties of a system. This biorecognition phenomenon is later converted into a detectable signal by the transducer. Biosensors can essentially serve as rapid and cost-effective devices with excellent sensitivity and specificity for critical purposes in innumerable fields, ranging from scientific research to day-to-day applications. Originality/value Here, the authors explain and discuss the approaches and challenges with the aim of leading to an interest in biosensor development and improving their applications.