JOURNAL OF NEUROSURGERY, vol.132, no.5, pp.1435-1446, 2020 (SCI-Expanded)
Article / Article
JOURNAL OF NEUROSURGERY
Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, MEDLINE
glioma, mutational signatures, DNA repair, exome sequencing, oncology, MUTATIONAL PROCESSES, PROMOTER MUTATIONS, GENE POLYMORPHISMS, NERVOUS-SYSTEM, IDH-MUTANT, CANCER, ASSOCIATION, SIGNATURES, PREDISPOSITION, PATTERNS
Dokuz Eylül University Affiliated:
OBJECTIVE Processes that cause or contribute to cancer, such as aging, exposure to carcinogens, or DNA damage repair deficiency (DDRd), create predictable and traceable nucleotide alterations in one's genetic code (termed "mutational signatures"). Large studies have previously identified various such mutational signatures across cancers that can be attributed to the specific causative processes. To gain further insight into the processes in glioma development, the authors analyzed mutational signatures in adult diffuse gliomas (DGs).