Sublingual nitrate plus 99tcm-tetrofosmin infusion in the detection of severely ischaemic but viable myocardium a comparative study with stress, redistribution, reinjection and late redistribution 201T1 imaging

DEREBEK E., Durak H., Ozbilek E., Capa G., Yurekli Y., Degirmenci B., ...More

Nuclear Medicine Communications, vol.17, no.10, pp.864-871, 1996 (SCI-Expanded) identifier identifier


To investigate the role of sublingual nitrate plus 99Tcm-tetrofosmin infusion in the detection of severely ischaemic but viable myocardium, we selected 25 patients with coronary artery disease who had at least one fixed segmental defect during conventional stress-redistribution (ST-RD) 201T1 single photon emission tomographic (SPET) imaging. Reinjection (RI) and 24 h late redistribution (LRD) imaging were also performed. Within a week of 201T1 imaging, one-day rest-stress (R-ST) 99Tcm-tetrofosmin SPET was performed with the same stress levels. The following day, 99Tcm-tetrofosmin was infused over 1 h immediately after sublingual nitrate administration and SPET images (N + Inf) were acquired. Of 100 fixed defects on R-ST 99Tcm-tetrofosmin imaging, 15 were reversible on N + Inf 99Tcm-tetrofosmin imaging. There was 91% concordance between ST-RD/RI/LRD 201T1 and R-ST/N + Inf 99Tcm-tetrofosmin imaging regarding reversibility. We conclude that N + Inf 99Tcm-tetrofosmin imaging may be clinically useful in the detection of severely ischaemic but viable myocardium. © 1996 Chapman and Hall ltd.