Sublingual nitrate plus 99tcm-tetrofosmin infusion in the detection of severely ischaemic but viable myocardium a comparative study with stress, redistribution, reinjection and late redistribution 201T1 imaging

DEREBEK E., Durak H., Ozbilek E., Capa G., Yurekli Y., Degirmenci B., ...Daha Fazla

Nuclear Medicine Communications, cilt.17, sa.10, ss.864-871, 1996 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 10
  • Basım Tarihi: 1996
  • Doi Numarası: 10.1080/00006231-199610000-00007
  • Dergi Adı: Nuclear Medicine Communications
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.864-871
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

To investigate the role of sublingual nitrate plus 99Tcm-tetrofosmin infusion in the detection of severely ischaemic but viable myocardium, we selected 25 patients with coronary artery disease who had at least one fixed segmental defect during conventional stress-redistribution (ST-RD) 201T1 single photon emission tomographic (SPET) imaging. Reinjection (RI) and 24 h late redistribution (LRD) imaging were also performed. Within a week of 201T1 imaging, one-day rest-stress (R-ST) 99Tcm-tetrofosmin SPET was performed with the same stress levels. The following day, 99Tcm-tetrofosmin was infused over 1 h immediately after sublingual nitrate administration and SPET images (N + Inf) were acquired. Of 100 fixed defects on R-ST 99Tcm-tetrofosmin imaging, 15 were reversible on N + Inf 99Tcm-tetrofosmin imaging. There was 91% concordance between ST-RD/RI/LRD 201T1 and R-ST/N + Inf 99Tcm-tetrofosmin imaging regarding reversibility. We conclude that N + Inf 99Tcm-tetrofosmin imaging may be clinically useful in the detection of severely ischaemic but viable myocardium. © 1996 Chapman and Hall ltd.