CNS INVOLVEMENT IN PRIMARY AND SECONDARY ALL AND TREATMENT STRATEGIES

CNS INVOLVEMENT IN PRIMARY AND SECONDARY ALL AND TREATMENT STRATEGIES

Sultan Okur Acar

Dokuz Eylul University Faculty Of Medicine, Tu€rkiye

Abstract Central nervous system (CNS) involvement is an important prognostic factor in acute lymphoblastic leukemia (ALL). Both primary and secondary CNS disease are associated with increased relapse risk and inferior survival. In adults, CNS involvement at diagnosis occurs in 5−10% of cases, with relapse rates of 4−15%. Before the introduction of prophylaxis in the 1980s, CNS relapse rates were as high as 30−40%. The pathophysiology of CNS involvement in ALL is complex, involving early migration of leukemic blasts across the blood −brain barrier, facilitated by adhesion molecules, integrins, and vascular endothelial growth factor (VEGF). VEGF-medi- ated endothelial disruption increases vascular permeability and plays a pivotal role in the development of posterior reversible encephalopathy syndrome (PRES). Targeting VEGF with monoclonal antibodies has been shown to reduce CNS leukemic burden, suggesting a promising future strategy in both pediatric and adult ALL. The immune-privileged micro- environment of the CNS provides a sanctuary for leukemic cells, supporting their persistence and relapse risk. Tradition- ally, cerebrospinal fluid (CSF) cytomorphology has been con- sidered the gold standard for assessing CNS involvement. However, this method has low sensitivity and specificity, par- ticularly in samples with low cell counts or technical artifacts. In recent years, flow cytometric immunophenotyping of CSF has demonstrated superior sensitivity, identifying CNS dis- ease more frequently and serving as a strong biomarker for relapse prediction. Minimal CNS involvement not only increases the risk of relapse but is also associated with treat- ment-related neurotoxicities. Data from the NOPHO group indicate that minimal CNS involvement in pediatric ALL is linked to higher rates of seizures and PRES. Standard treatment approaches continue to rely on intrathecal che- motherapy (methotrexate, cytarabine, corticosteroids) and high-dose systemic agents. However, repeated intrathecal administration and cranial irradiation carry substantial risks of long-term neurotoxicity, highlighting the need for

more selective and less toxic strategies. Radiation therapy may still be considered in selected cases, particularly in the context of hematopoietic stem cell transplantation (HSCT). HSCT remains a potentially curative option, especially when preceded by effective cytoreduction with immuno- therapy. In conclusion, CNS involvement in ALL represents a biologically and clinically distinct entity requiring tailored management. Primary involvement demands sensitive diagnostics and a careful balance between efficacy and neu- rotoxicity, while secondary CNS relapse necessitates aggressive multimodal therapy, often incorporating novel immunotherapies and HSCT. Advances in CNS-directed diagnostics and therapeutics are expected to further indi- vidualize treatment, aiming to reduce relapse risk while minimizing late toxicities.

https://doi.org/10.1016/j.htct.2025.106192