Tc-99m HMPAO brain perfusion SPECT in drug-free obsessive-compulsive patients without depression

ALPTEKİN K., Degirmenci B., Kivircik B. B., Durak H., Yemez B., Derebek E., ...Daha Fazla

PSYCHIATRY RESEARCH-NEUROIMAGING, sa.1, ss.51-56, 2001 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1016/s0925-4927(01)00086-5
  • Dergi Adı: PSYCHIATRY RESEARCH-NEUROIMAGING
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.51-56
  • Anahtar Kelimeler: Yale-Brown Obsessive-Compulsive Rating Scale, thalamus, orbitofrontal cortex, cross-cultural, GLUCOSE METABOLIC RATES, CEREBRAL BLOOD-FLOW, COMPUTED-TOMOGRAPHY, MAGNETIC-RESONANCE, CAUDATE-NUCLEUS, DISORDER, ABNORMALITIES
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

The aim of this study was to confirm prior results of brain-imaging studies on obsessive-compulsive disorder (OCD) in a sample of Turkish patients, as a cross-cultural study. Tc-99m HMPAO brain perfusion SPECT imaging was performed in nine drug-free OCD patients without depression and six controls. The patients' Hamilton Depression Rating Scale scores were < 16. The severity of obsessive-compulsive symptoms was rated with the Yale-Brown Obsessive-Compulsive Rating Scale (YBOCS). Quantitative evaluation of regional cerebral blood flow revealed that right thalamus, left frontotemporal cortex and bilateral orbitofrontal cortex showed significant hyperperfusion in patients with OCD compared with controls. YBOCS scores did not show any correlation with hyperperfusion in regional cerebral blood flow in these areas. Results of this cross-cultural study may support orbitofrontal and thalamic dysfunction in OCD in a sample of Turkish patients. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.