Prognostic factors in resected non-small cell lung cancer with pathological N1 lymph node involvement: a survival analysis
JOURNAL OF CARDIOTHORACIC SURGERY, cilt.21, sa.1, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 21 Sayı: 1
- Basım Tarihi: 2026
- Doi Numarası: 10.1186/s13019-026-04041-9
- Dergi Adı: JOURNAL OF CARDIOTHORACIC SURGERY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE, Directory of Open Access Journals, Academic Search Ultimate (EBSCO), Biomedical Reference Collection: Corporate Edition (EBSCO), Health Research Premium Collection (ProQuest)
- Dokuz Eylül Üniversitesi Adresli: Evet
Özet
Background This study aimed to evaluate the prognostic factors influencing survival in patients who underwent surgical treatment for early-stage non-small cell lung cancer (NSCLC) and were found to have N1 lymph node metastasis on pathological examination. Methods A total of 66 NSCLC patients who underwent anatomic lung resection (lobectomy, bilobectomy, or pneumonectomy) at our clinic between 2010 and 2020 and had a pathological stage of T1-2N1M0 disease were retrospectively analyzed. Clinical, demographic, histopathological, and surgical data, as well as survival times, were evaluated. Survival analyses were performed via the Kaplan-Meier method, and prognostic variables were assessed via univariate and multivariate analyses. Results A total of 66 patients, 60 males and 6 females, were included in the study. The mean age was 63.7 +/- 8.3 years. The mean overall survival was 59.7 months, and the disease-free survival was 52.0 months. Squamous cell carcinoma histology, central tumor location, the presence of occult lymph node metastasis, and visceral pleural invasion were significantly associated with survival (p < 0.05). Cox regression analysis revealed that the histological subtype and the visibility of N1 metastasis were identified as independent prognostic factors. Conclusion Pathological N1 lymph node involvement has a significant effect on the prognosis of patients with NSCLC. In particular, histological subtype and the presence of occult metastasis are key determinants of survival.