Lamivudine and adefovir resistance in children and young adults with chronic hepatitis B

Akman S. A., Kose Ş., Halicioglu O.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, cilt.14, sa.3, 2010 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 3
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.ijid.2009.04.002
  • Dergi Adı: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Lamivudine, Adefovir, Resistance, Hepatitis B, VIRUS INFECTION, DIPIVOXIL, EFFICACY, MUTATION, MUTANTS, THERAPY, SAFETY, HBV
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

Objective: Long-term lamivudine (LAM) and adefovir (ADV) treatment has been found to induce the emergence of drug-resistant hepatitis B virus (HBV) in a significant number of patients with chronic hepatitis B (CHB) infection. The aim of our study was to evaluate the LAM and ADV mutations detected in our patient group.