Tenascin C and cathepsin D expression in adipocytic tumors: An immunohistochemical investigation of 43 cases

Sis B., Tuna B., Yorukoglu K., Kargi A.

INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY, vol.12, no.1, pp.11-15, 2004 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 1
  • Publication Date: 2004
  • Doi Number: 10.1177/106689690401200102
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.11-15
  • Keywords: cathepsin D, tenascin C, lipoma, atypical lipomatous tumor, liposarcoma, BREAST-CANCER, LARYNGEAL, PROLIFERATION, METASTASIS
  • Dokuz Eylül University Affiliated: Yes


Cathepsin D (CatD) and tenascin C (Tn-C) have been implicated in invasion and metastasis of carcinomas. However, little is known about Calf) and Tn-C distribution in mesenchymal tumors. Therefore, we aimed to investigate the expression of Tn-C and Catl) in adipocytic tumors. Tn-C and CatD expressions in 27 lipomas, 5 atypical lipomatous tumor/well-differentiated liposarcomas (ALT/WDLS) and 11 liposarcomas (LS) were evaluated by immunohistochemistry and scored serniquantitatively. CatD expression was higher in ALT/WDLS than in lipomas (p<0.001), and higher in LS than in ALT/WDLS (p = 0.009). Stromal Tn-C expression was higher in ALT/WDLS than in lipomas (p = 0.02), but no difference was observed between ALT/WDLS and LS (p > 0.05). These results indicate that Tn-C and Calf) may be markers of locally aggressive or malignant behavior in adipocytic tumors.