Cup-like Blasts in 2 Pediatric Patients With NPM-1-Positive Acute Myeloid Leukemia

TÜFEKÇİ Ö., Erdem M., ÖREN H., YILMAZ Ş.

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, cilt.40, sa.4, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Editöre Mektup
  • Cilt numarası: 40 Sayı: 4
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1097/mph.0000000000001110
  • Dergi Adı: JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: acute myeloid leukemia, cup-like blast, Npm-1, ASSOCIATION, NUCLEI, FLT3
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Cup-like phenotype is defined in some subtypes of acute myeloid leukemia (AML) and have been associated with NPM-1 and/or FLT3-ITD positivity in the presence of normal karyotype in >60% of patients. Herein we present two pediatric AML-M1 patients with cuplike nuclear morphology and NPM-1 positivity. Both patients were negative for FLT3-ITD mutation. NPM-1 mutation and FLT3-ITD mutation should be kept in mind in AML patients with cup-like blast morphology as these two mutations are important molecular markers for prognosis, risk group classification and also for response to treatment.