Synthesis and bio-molecular study of (+)-N-Acetyl-a-amino acid dehydroabietylamine derivative for the selective therapy of hepatocellular carcinoma

Mustufa, Muhammad; Ozen, Cigdem; Hashmi, Imran; Aslam, Afshan; Baig, Jameel; YILDIZ, GÖKHAN; Muhammad, Shoaib; Solangi, Imam; Naqvi, Naim; Ozturk, Mehmet; Ali, Firdous

doi:10.1186/s12885-016-2942-5

Synthesis and bio-molecular study of (+)-N-Acetyl-a-amino acid dehydroabietylamine derivative for the selective therapy of hepatocellular carcinoma

Mustufa M. A., Ozen C., Hashmi I. A., Aslam A., Baig J. A., YILDIZ G., ...More

BMC CANCER, vol.16, 2016 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 16
Publication Date: 2016
Doi Number: 10.1186/s12885-016-2942-5
Journal Name: BMC CANCER
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Keywords: Dehydroabietylamine derivatives, Hepatocellular carcinoma, Cytotoxicity, Connectivity map, Apoptosis
Open Archive Collection: AVESIS Open Access Collection
Dokuz Eylül University Affiliated: Yes

Abstract

Background: The purpose of present work is to synthesize novel (+)-Dehydroabietylamine derivatives (DAAD) using N-acetyl-a-amino acid conjugates and determine its cytotoxic effects on hepatocellular carcinoma cells.