Synthesis and bio-molecular study of (+)-N-Acetyl-a-amino acid dehydroabietylamine derivative for the selective therapy of hepatocellular carcinoma

Mustufa, Muhammad; Ozen, Cigdem; Hashmi, Imran; Aslam, Afshan; Baig, Jameel; YILDIZ, GÖKHAN; Muhammad, Shoaib; Solangi, Imam; Naqvi, Naim; Ozturk, Mehmet; Ali, Firdous

doi:10.1186/s12885-016-2942-5

Synthesis and bio-molecular study of (+)-N-Acetyl-a-amino acid dehydroabietylamine derivative for the selective therapy of hepatocellular carcinoma

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Mustufa M. A., Ozen C., Hashmi I. A., Aslam A., Baig J. A., YILDIZ G., ...More

BMC CANCER, vol.16, 2016 (SCI-Expanded)

Publication Type: Article / Article
Volume: 16
Publication Date: 2016
Doi Number: 10.1186/s12885-016-2942-5
Journal Name: BMC CANCER
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Keywords: Dehydroabietylamine derivatives, Hepatocellular carcinoma, Cytotoxicity, Connectivity map, Apoptosis, IN-VITRO, CANCER, ASSAY
Dokuz Eylül University Affiliated: Yes

Abstract

Background: The purpose of present work is to synthesize novel (+)-Dehydroabietylamine derivatives (DAAD) using N-acetyl-a-amino acid conjugates and determine its cytotoxic effects on hepatocellular carcinoma cells.