Synthesis and bio-molecular study of (+)-N-Acetyl-a-amino acid dehydroabietylamine derivative for the selective therapy of hepatocellular carcinoma

Mustufa, Muhammad; Ozen, Cigdem; Hashmi, Imran; Aslam, Afshan; Baig, Jameel; YILDIZ, GÖKHAN; Muhammad, Shoaib; Solangi, Imam; Naqvi, Naim; Ozturk, Mehmet; Ali, Firdous

doi:10.1186/s12885-016-2942-5

Synthesis and bio-molecular study of (+)-N-Acetyl-a-amino acid dehydroabietylamine derivative for the selective therapy of hepatocellular carcinoma

Mustufa M. A., Ozen C., Hashmi I. A., Aslam A., Baig J. A., YILDIZ G., ...Daha Fazla

BMC CANCER, cilt.16, 2016 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 16
Basım Tarihi: 2016
Doi Numarası: 10.1186/s12885-016-2942-5
Dergi Adı: BMC CANCER
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Anahtar Kelimeler: Dehydroabietylamine derivatives, Hepatocellular carcinoma, Cytotoxicity, Connectivity map, Apoptosis
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background: The purpose of present work is to synthesize novel (+)-Dehydroabietylamine derivatives (DAAD) using N-acetyl-a-amino acid conjugates and determine its cytotoxic effects on hepatocellular carcinoma cells.