Effect of analgesia administration timing on early post-operative period characteristics: A randomized, double-blind, controlled study

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Mavioglu O., Ozkardesler S., Tasdogen A., Akan M., Canduz B.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, cilt.33, sa.5, ss.483-489, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 5
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1177/147323000503300502
  • Dergi Adı: JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.483-489
  • Anahtar Kelimeler: pethidine, pain management, timing of analgesia, post-operative period, PATIENT-CONTROLLED ANALGESIA, PREEMPTIVE ANALGESIA, MORPHINE, PAIN, PETHIDINE
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

This study investigated the effect of time of analgesia administration in 64 patients undergoing total abdominal hysterectomy. Patients received standard general anaesthesia and were divided randomly into two equal groups. At the time of fascia closure, patients in the intra-operative (lop) group received 0.5 mg/kg pethidine intravenously. On arrival in the post-anaesthesia care unit, the same dose of pethidine was given to patients in the postoperative (Pop) group. All patients then used a patient-controlled analgesia pump to administer pethidine analgesia as required. Times to extubation, response to verbal stimulation and orientation, postoperative pain scores and analgesic consumption were recorded. Times to extubation and response to verbal stimulation were significantly longer in the lop group. Pain scores, analgesic consumption and additional analgesic requirements were significantly higher in the Pop group in the first 2 h postoperatively. In conclusion, intra-operative administration of pethidine provided better pain management than postoperative administration.