Effect of analgesia administration timing on early post-operative period characteristics: A randomized, double-blind, controlled study
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, vol.33, no.5, pp.483-489, 2005 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 33 Issue: 5
- Publication Date: 2005
- Doi Number: 10.1177/147323000503300502
- Journal Name: JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.483-489
- Keywords: pethidine, pain management, timing of analgesia, post-operative period
- Open Archive Collection: AVESIS Open Access Collection
- Dokuz Eylül University Affiliated: Yes
Abstract
This study investigated the effect of time of analgesia administration in 64 patients undergoing total abdominal hysterectomy. Patients received standard general anaesthesia and were divided randomly into two equal groups. At the time of fascia closure, patients in the intra-operative (lop) group received 0.5 mg/kg pethidine intravenously. On arrival in the post-anaesthesia care unit, the same dose of pethidine was given to patients in the postoperative (Pop) group. All patients then used a patient-controlled analgesia pump to administer pethidine analgesia as required. Times to extubation, response to verbal stimulation and orientation, postoperative pain scores and analgesic consumption were recorded. Times to extubation and response to verbal stimulation were significantly longer in the lop group. Pain scores, analgesic consumption and additional analgesic requirements were significantly higher in the Pop group in the first 2 h postoperatively. In conclusion, intra-operative administration of pethidine provided better pain management than postoperative administration.