Aim: The aim of this study is to examine the unique and interactive role of worry and rumination in anxiety and depression symptoms. Method: A total of 328 university students responded to questionnaires assessing worry (Penn State Worry Questionnaire), rumination (Ruminative Response Scale-Short Version), anxiety (Beck Anxiety Inventory and Trait Anxiety Inventory), and depression (Beck Depression Inventory). Results: The results of regression analyses demonstrated that the relationship between worry and depressive symptoms is significant only if individuals engage in high levels of brooding type rumination. The main effect of worry was a significant predictor of trait anxiety, but it did not make a significant contribution to somatic anxiety. Brooding was found to be associated not only with depressive symptoms but also with both types of anxiety. Finally, the reflection type of rumination did not significantly predict depressive symptoms, somatic anxiety, or trait anxiety. Conclusion: Findings indicated that worry and rumination are related to both anxiety and depression. Clinical implications of these results were discussed in the light of the current literature.