Neuron specific enolase levels in renal cell carcinoma

Çinar T., Akan G., Kirkali G., YÖRÜKOĞLU K., Kirkali Z.

British Journal of Urology, cilt.80, ss.133, 1997 (SCI-Expanded, Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 80
  • Basım Tarihi: 1997
  • Dergi Adı: British Journal of Urology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.133
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Renal cell carcinoma (RCC) constitutes 3% of all adult solid tumors and there is no effective treatment other than surgery. Currently there exists no tumor marker for RCC, and early diagnosis relies on the liberal use of abdominal ultrasound. Fourteen patients were operated for RCC at our institution between August 1989 and December 1993 and included in this study Neuron specific enolase (NSE) levels in normal and tumor tissue were measured by biochemical and immunohistochemical methods A significant difference was detected between NSE levels of normal renal tissue and RCC (p=0.0065). There was no difference between NSE levels, stage, grade and nuclear differantiation of the tumor. Immunohistochemical studies showed that 8 tumors were stained more than the normal tissue, no staining was observed in 5 tumors and paradoxically 1 normal tissue was stained more than the tumor. The importance of NSE as a tumor marker in RCC will be better understood by other studies including tissue and serum levels.