Association of Initial Disease-Modifying Therapy With Later Conversion to Secondary Progressive Multiple Sclerosis


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Brown J. W. L., Coles A., Horakova D., Havrdova E., Izquierdo G., Prat A., ...More

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, vol.321, no.2, pp.175-187, 2019 (SCI-Expanded) identifier identifier identifier

Abstract

IMPORTANCE Within 2 decades of onset, 80% of untreated patients with relapsing-remitting multiple sclerosis (MS) convert to a phase of irreversible disability accrual termed secondary progressiveMS. The association between disease-modifying treatments (DMTs), and this conversion has rarely been studied and never using a validated definition.