Investigation of the relation between thrombocyte counts and serum transaminases in patients with Crimean Congo hemorrhagic fever

Barut S., Gemici U., Demir O., Gunes F.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.42, no.3, pp.365-368, 2017 (SCI-Expanded, Scopus, TRDizin) identifier identifier

  • Publication Type: Article / Article
  • Volume: 42 Issue: 3
  • Publication Date: 2017
  • Doi Number: 10.1515/tjb-2017-0023
  • Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.365-368
  • Keywords: Crimean-Congo hemorrhagic fever, AST, ALT, Thrombocyte count
  • Dokuz Eylül University Affiliated: No

Abstract

Objective: Fever, thrombocytopenia and transaminase elevation are consistent features of Crimean-Congo hemorrhagic fever (CCHF). This study which was done in a hyperendemic region for CCHF, was carried out to find the frequencies of elevated transaminases among CCHF patients with thrombocytopenia. Methods: Thrombocyte counts, aspartate aminotransferase (AST), alanine aminotransferase (ALT) test results on admission and follow-up of hospitalized CCHF patients were collected retrospectively. Results: When we assessed data on admission, all patients with thrombocyte <= 50,000/mu L had elevated AST as well as all but one (98.1%) had elevated ALT levels. When the lowest thrombocyte count was taken into account, concordant AST, ALT levels of all patients with thrombocyte <= 50,000/mu L were above normal. Conclusion: Conclusively, acute CCHF patients with thrombocyte <50,000/mu L should necessarily have elevated ASTs, ALTs.