Modulation of radiation-induced oral mucositis (mouse) by dermatan sulfate: effects on differentiation processes


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Cini N., Gruber S., Alicikus Z. A., Dorr W.

STRAHLENTHERAPIE UND ONKOLOGIE, vol.196, no.1, pp.85-94, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 196 Issue: 1
  • Publication Date: 2020
  • Doi Number: 10.1007/s00066-019-01532-8
  • Journal Name: STRAHLENTHERAPIE UND ONKOLOGIE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CINAHL, EMBASE, MEDLINE
  • Page Numbers: pp.85-94
  • Keywords: Fractionation, Proliferation, Differentiation, Cellular junctions, Mechanical strength, EXPRESSION, SKIN, PENTOXIFYLLINE, PROTEINS, P53
  • Dokuz Eylül University Affiliated: Yes

Abstract

Purpose During head and neck cancer radiotherapy, oral mucositis is the most frequent early side effect. Systemic dermatan sulfate (DS) administration has been shown to significantly decrease oral mucosal radiation reactions during daily fractionated irradiation (IR) in an established mouse model. The aim of this study was to investigate the mechanism of the oral epithelial differentiation process, during IR alone and in combination with DS treatment in the same mouse model.