Modulation of radiation-induced oral mucositis (mouse) by dermatan sulfate: effects on differentiation processes

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Cini N., Gruber S., Alicikus Z. A., Dorr W.

STRAHLENTHERAPIE UND ONKOLOGIE, cilt.196, sa.1, ss.85-94, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 196 Sayı: 1
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1007/s00066-019-01532-8
  • Dergi Adı: STRAHLENTHERAPIE UND ONKOLOGIE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CINAHL, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.85-94
  • Anahtar Kelimeler: Fractionation, Proliferation, Differentiation, Cellular junctions, Mechanical strength, EXPRESSION, SKIN, PENTOXIFYLLINE, PROTEINS, P53
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Purpose During head and neck cancer radiotherapy, oral mucositis is the most frequent early side effect. Systemic dermatan sulfate (DS) administration has been shown to significantly decrease oral mucosal radiation reactions during daily fractionated irradiation (IR) in an established mouse model. The aim of this study was to investigate the mechanism of the oral epithelial differentiation process, during IR alone and in combination with DS treatment in the same mouse model.