Relationship between Serum Adipocyte Fatty Acid-Binding Protein Levels and Systemic Inflammation in Hemodialysis Patients

Korucu B., Derici M. K., Deger S. M., Cokay A., HELVACI Ö., Elbeg S., ...More

TURKISH JOURNAL OF NEPHROLOGY, vol.29, no.2, pp.115-121, 2020 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 2
  • Publication Date: 2020
  • Doi Number: 10.5152/turkjnephrol.2020.3686
  • Journal Name: TURKISH JOURNAL OF NEPHROLOGY
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.115-121
  • Keywords: Adipocyte fatty acid-binding protein, cardiovascular diseases, hemodialysis, systemic inflammation, EPICARDIAL ADIPOSE-TISSUE, LIPID-METABOLISM, APOLIPOPROTEIN-E, OBESITY, BIOMARKER, AP2, EXPRESSION, DEFICIENT, DISEASE, PREDICT
  • Dokuz Eylül University Affiliated: No

Abstract

Objective: Adipocyte fatty acid-binding protein (A-FABP) is expressed in adipose tissue and macrophages. It regulates cholesterol trafficking and is involved in atherosclerosis formation. A-FABP levels are associated with cardiovascular diseases (CVDs) in patients with or without chronic kidney disease. In this study, we evaluated A-FABP levels in healthy controls and hemodialysis (HD) patients and compared the results with C-reactive protein (CRP) and interleukin-6 (IL-6) levels to determine their relationship with systemic inflammation.