Guillain-Barré syndrome (GBS) is a peripheral polyneuro radiculopathy with acute onset which is most commonly characterized by rapidly progressive symmetric weakness and areflexia. Infectious agents, surgery or immunizations may trigger the formation of the disease. An 11-year-old boy was admitted to the hospital after presenting weakness and symptoms of walking disabilities three weeks after the influenza vaccination. The neurologic examination revealed a symmetric proximal muscle weakness of upper and lower extremities, Gower's sign and absent deep tendon reflexes. Cerebrospinal fluid analysis revealed an albuminocytologic dissociation. Therefore, a diagnosis of GBS following vaccination was made. While studies have found inconclusive results on the association between influenza vaccine and GBS, all suspected cases should be published for further evaluation and investigated with the aid of literature.